I try to not take off more than two consecutive days - not everyone's rule, just my personal one. Sometimes, I just don't feel like it so I tell my self to just go around a few blocks or wherever and feel free to come home if i can't or don't want to do it. At least 9/10 times, I'll get a decent ride in. On the 10th time, I'll turn around after a couple miles but I still feel better and seem to be fine the next day.

Of course, YMMV.