2017 Domane SL6, have about 5,000 miles on Isospeed front/rear, I weight 230lbs and run 32 mm tires at 80 psi.
Definitely smoother on typical real world roads, no noticeable bounce or negative effects. I don't have the adjustable rear but with the standard version when I hit potholes they still feel like potholes - the amount of travel is great for rough road buzz but not that much difference to me on bigger impacts. Still a major plus for me.