My friend tends to be a lower-rpm pedaler, which optimizes his strengths (can squat over 400#) and minimizes the downside of having such heavy legs (more work to spin them quickly).

I know the current owner of the bike, and the bike has been well cared-for and hasn't seen a lot of use. I'm comfortable on that front, in a way that I generally wouldn't be about a used botique wheelset.
I don't care for the Zondas, and they're not what I'd want on a bike for my 220# buddy. They just happen to be on the bike, and with Campy 10-speed it's more expensive to get a new wheelset than with 8/9/10 Shimano-compatible wheels. (A Shimano-type wheelset and cassette with a travel agent for rear der is another option if my friend buys this bike.)

I'm leaning away from this unless I can get a different (more standard) wheelset. My friend would be a good match for Sun CR18 (36 rear, 32 front) standard wheelset.