Originally Posted by northbend

This is good advice. Along with possibly raising the stem a bit for less saddle to bar drop.

I have em on my fixed gear which is set up as crank addict has advised putting me in a slightly more upright position. I find it comfortable enough (even though there are fewer hand positions than a drop bar) for long distances (for example, the one day STP double century and 150 mile RAMROD).
The only negative I've experienced personally is the lack of a true aero position when dealing with headwinds. Putting your hands one the brake hoods and bending your elbows only goes so far and is tiring for my skinny tyrannosaurus like arms..

IMG_1195 by NBend, on Flickr