A few comments.

Frame- Some Ti frames use 64 Ti for the drop outs (being plates and not having the manipulation that making a tube goes through). This alloy is very hard and there have been many reports of axle coming loose in this kind of drop out material.

QR- I would strongly suggest you use only steel capped QR skewers with an internal cam design. Not only do these QRs have greater gripping ability then a QR with Al end caps the over center cam action can apply greater clamping forces then a wing nutted design. (Like the "fancy" DT's photoed, which are basically just very expensive wing nuts. To their credit, at least, they do use steel gripping surfaces)

QR- I also suggest a steel (not Ti) skewer shaft as Ti has greater stretch then steel has.

QR- lastly make sure that a conical QR end spring isn't installed wrong. All kinds of securement issues happen when the big end of the spring is sandwiched between the axle, the QR end cap and the drop out. This is far easier to do then those who do it want to admit Andy