Never have had Lyme Disease.

But having been a fair distance runner who loved heading into the "hills," back in the day, I've had more than my share of various infections and whatnot, tick-borne or otherwise.

I have always kept to this basic guideline, whether due to illness or injury: if after my training was back to normal, and if I could do at least one instance of the given intended distance+pace+route, then I would consider myself good to go. Otherwise, I'd remain focused on getting better and back to "race" quality.

IOW, the "Better Safe Than Sorry" method.

I suspect it'd be a good guideline to adhere to irrespective of the sport in question. Helped keep me healthier, when pushing things beyond simple outings. Held me back, some, I suppose, but I believe that I recovered well enough at least in part due to this method.

Good luck in the recovery.