I beg to differ. I Can't comment on 406 vs. 451 (the only bike with 451s I've ever ridden was a Chinese BSO, and it still was a PoS after I swapped its factory 451s out for a pair of 451 Primo Comets that cost about twice as much as the entire bike was worth when new,) but I could tell you with a decent amount of conviction that my bygone Vybe D7 rode and handled very differently from my Speed D8 or Mu D8.

Heck, even my Mu D8 and my Speed D8 are more or less distinct in the way they go down the road, even with both having identical geometry and componentry, right down to the exact same rims and tires! In fact, if you blindfolded me and towed me behind your vehicle, I could easily tell you which of the two I'm on.

With all due respect, it would be just wrong - let alone unhelpful - to push the notion that "if you've ridden one, you've ridden them all."