That's a tough one. My dad got Lyme disease in his 60s and it wasn't diagnosed early enough to prevent the worst consequences. Hard to tell how much it affected him since he also battled cancer for several years. But overall the combination slowed him down a lot.
A friend in New England was just recently diagnosed with Lyme after weeks of some vague and misdiagnosed symptoms. Her doctor believes they caught it early enough to treat effectively. I think she's back to work now. Tough year for her also since she was already struggling with an old neck injury.
On bike rides I used to carry individual packets of wipes containing sunscreen and bug repellent. I stopped carrying those when I got road bikes with minimal saddle bags. But I really need to remember to at least spray my legs with bug repellent before heading out, for those roadside pit stops.