Originally Posted by
ThermionicScott
Some of the current thinking around "sub-compact" cranks is actually to keep the ~46T big ring centered with the cassette. That way, one can just stay in the big ring and use the full range of the cassette, only shifting to the small ring for steep and/or long climbs. With modern chains, wear and efficiency aren't drastically worse in the big-big and top gear combinations than they are in the neighboring combinations.
But I agree the OP ought to just go ahead and try things. Experience is the best teacher.

Especially when tempered with skill, proper tools and most of all common sense, IMO.