I love that Domane - I'm not a racer, more a long distance recreational and touring rider. The Isospeed dampers made the ride noticeably different/better to me when I did my test rides (in a warm February!) along with the SL6 basr and padded bar tape. My first carbon and disc brake bike - I'm big fans of both now.

The only downside has been the need to pay more attention to care for the carbon frame - not clamping the top tube on my work stand, using torque wrenches, having a press in bottom bracket, etc. Always rode steel bikes before this.

Two minor nits that Trek seems to have fixed:

• The plastic cable guide on the bottom bracket kept snapping, about every 1500 miles or so. First, fix was under warranty, Trek OKed bike shop fixing second one outside of warranty. Third time the bike shop said "Trek sent us replacement guides, we'll put one of the new ones on for free." That one has lasted 2 years now.
• I sprung for the DI2 rpm/speed sensor. Kind of annoying to replace the battery - have to remove the rear wheel, though maybe folks with smaller hands can reach between the spokes Plus, the rubber band mount for the crank magnet lasted about as long as the cable guide - I ended up just gluing a magnet on the crank. I think someone said Trek improved the rubber band for the larger cranks, but don't know.