Boost spacing would allow 700x45 with shorter chainstays and 2x compatibility. But I don't think CS length is that big a deal in this segment. Boost spacing would also mean no one's existing gravel/road wheels would fit.

I think the '21 Checkpoint will be more like the new Domane (which I have) : front Iso, rear Iso but probably not adjustable, DT storage, 2x & 700x42c /650b clearance, maybe semi-tucked cables.

Same 600 series as current bike, whereas the Domane SLR is the much costlier 700 series carbon. I would like to see a Pro Endurance geometry option for the next Checkpoint.

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