My wife and I just got the Santana Niobium with S & S couplers. Our local shop (Bicycle Outfitter) not only assured me that the bike would fit in 2 soft backpack style cases, the shop actually insisted that we get this style of case rather than the Santana hard case as the shop has had much better luck with the soft cases purchased directly from S & S.
As with all Santana coupled bikes, ours splits into a front triangle, rear triangle, and 3 separate middle tubes. That break does not seem to preclude or interfere with the use of two cases rather than one. We are still waiting for the cases, so I have not tried packing the bike yet, but I trust that the shop knows what it is doing.
Ira