From what I have found you have to be willing to use MTB cranks. The bike pictured below is a drop bar gravel bike ( it has a 44mm head tube with reworked lugs) and has a Continental Race King 2.2 tire installed. Its a lugged frame with paragon disc mounts. As you can see there is plenty of clearance between the crank/chainstay and tire/chainstay. If I remember it takes some massaging of the BB CS angle to get them wide enough. It has a 39 tooth big ring on it in the pic, you can get up to a 42 tooth on the stock Sram cranks, there are aftermarket rings that go bigger, I have not found a Shimano that goes past 40 teeth. Raceface makes a mtb crank, 30mm spindle, that accepts an Easton Cinch chainring set 46/30. The Raceface crank is about 7mm wider than a standard mtb crank and allows for shimming so it might fit.

I am currently working on another frame and plan to use a GRX 46/30 crank, not sure what the max tire width will be but for this one i am looking for somewhere around 50mm between the stays and doing a mock up it looks ok. I'll know in the next week or so.