Buy the bike you want to ride, have it fit to you so that you are comfortable riding, and upgrade your wheels.

Get a set of wheels for a tandem bike as they are designed for weight.

When I started riding I couldn't go any distance as I was too bent over thus had breathing trouble due to my belly forcing organs into tighter spaces. By putting a different stem on the bike that allowed me to sit more upright I was able to ride some distances without discomfort.

If the bike is not the style you want to ride you won't ride.

Also Specialized and Trek make good bikes, but they do have lawyer limits (weight limits), but many other bike manufactures out there like Orbea and Bianchi don't have these limits.

I am 365 pounds at 6'3" and ride an Orbea Orca with Rolf Vigor RS wheels (24 spoke count front and rear, but spokes are not indexed in the traditional cross manor).