What do you mean by chainline ?

Normally, the chainline is the distance between the chain and the center axle of the bike = center of the hub of the wheels.

Changing the size of the chainwheel doesn't change the chainline.

It seems to me that what you call chainline is the height of the upper part of the chain that could hit the right rear arm at the place where a protection is placed on it.

This could be a problem with huge cassettes with 42t till 50t biggest cog but not with 32t to 36t, R&M mount a 9-32 cassette and there is more space for a bigger cog. Changing from 10s to 11s doesn't really change the position of cassette.

But such a big cog is not really necessary with a small ETRTO 355 rear wheel.