I have found that if I put Nuun in my water bottle for a long ride I feel better for it . Recently I have discovered that if I eat prior to my morning ride I don’t feel good. I get slight cramping even after my morning constitutional. I take a breakfast bar with me and after about 15 miles or so I stop and snack with my mineral supplements and no problem. I am vegan and have no other digestive issues. As far as seat issues I always wear cycling shorts or undies for padding.