I've seen some recently that are pretty nice, the Norco Indie 2 (2" tires), Brodie Tesla (2.2" tires). The Norco seems real sweet because it has the same 46/30 gearing for the crankset as the Shimano GRX gravel group.
The Opus Big City has 650b x 45mm tires so I guess they didn't get the memo. If you have large tires like 2.1" in 650b, then it would give you the advantage of having the same circumference as a small tire on 700c. 45mm is small enough you'd lose speed overall...