So Andy,
Does that mean eating left side granola vs right side granola? I sponsor a short track car that turns 7300+ rpm, but we still have to balance the car on the track. Our work to balance the the engine to spin at those rates is just like polishing bearing races on wheels, so they spin easier. Balancing the wheels is just part of it. Taking vibration out of the car is important to getting to be able to balance the car on the track. This also applies the a bike rider and racer. Remove any variables and it makes the riding and competing easier. I am of the opinion that optimizing every aspect is important.
I have been the recipient of a ride into a corn field off the road from a wheel that was out of balance. Just like the pump in the wheel scene in Breaking Away. I have long since disposed of both the wheel set and the frame, as I lost faith in both of those. I still have a firm belief in balancing the wheels on all vehicles, two wheeled, three wheeled , or four. Just my experience, and opinion. Smiles, MH