Originally Posted by
BassistBiker
Here's the setup (sorry for the late reply...been a silly busy week).
The pic of the bike has kind of an optical illusion, it looks like the saddle is "nose down" but on level ground, using an actual level, it's almost perfectly flat...maybe 2-3 degrees high on the nose.
I took a few days off, lowered my saddle by 5mm and lowered the saddle nose to where it is pictured now. I took a short 11 mile ride today, and the saddle feels....OK, but now I've developed some slight knee pain on my right leg (pain that goes over the kneecap top to bottom), I "think" the 5mm saddle drop is too much, I think I'm going to try the saddle at the angle it is now, but raise it back up to where I originally had it.

If you have to tip the nose of the saddle down so much, I can almost guarantee you are starting with it too high. There is not way you can have the weight on your sit bones with the saddle set up like that. Try dropping it, and getting the saddle level to start, then make small adjustments from there.