Find the tilt that works for you. This will depend a good part on the seat. Many who ride traditional all leather seats like the nose up. But it also depends on you handlebar location and how much forward bend you have. I am long and shinny without a lot of power, Low bars and a good aero position make life a lot more bearable going upwind. But seats that are not nose down make my life miserable.

I consider the exact tilt probably the most critical setting on the bike. I hate seatposts with click-stops and by far favor seatposts with 2-bolt clamps where you can back off one bolt, tweak the other a tiny bit, re-tighten the first and do little tilt changes that are just as easy to undo. When setting up a bike, I set the height exactly to that of another bike with similar seat. Then get the seat close by eye and go for a ride, wrenches to adjust height and tilt in my pocket.

Ben (Edit for a funny typo)