Well, for me this is a very reliable hint that seat height is significantly higher than it should be - this causes asymmetrical seating position as body is forced to choose which side of the body will suffer (it'll try to protect the dominant side of the body). Cobb San Remo worked great for me for perineal pressure - no pressure at all. But this pressure depends a lot on the saddle angle - as with any other seat. Try changing seat angle from completely flat to, say, 3 degrees nose up - in 0.5 degree increments at a time, or even less. Difference is usually striking, at least for me it is. E.g. with San Remo for me in my current riding position 0.7 to 1 degree work best, less or more are both worse - which is why adjusting seat angle by sight only is IMHO completely useless.