A friend of mine did exactly what you are trying a few months back with no problems. I don't remember make of bike although it was a hybrid with v-brakes. He liked the bike but wanted to switch to drop bars. Used Microshift road brifters with travel agents. The Microsoft brifters work fine with his Shimano derailleurs. As I remember it, the left shift lever has multiple "clicks" to allow for fine tuning the position of the front derailleur to the chain line. The cost of brifters and travel agents wasn't cheap but he ended up happy with his new ride.