Seems like you’re already sold on di2, why worry about whether or not the frameset is worthy?

Heck, there’s no rules against putting a 2016 Corvette LS engine into a 1975 Mercury Bobcat- you can put di2 onto a Centurion Ironman or a Surly Cross Check if that’s what boats your goat.

You can even mix di2 with non-carbon wheels, even non-aero wheels!

shucks, now I want to see a GMC Denali frameset with di2 and sun cr-18 wheels.

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personally, I think that if you must have gears and you have enough disposable income, Rohloff on a Riv Roadeo is the only answer. Painted red, of course.