My PSA rises when actively riding. I know it side I get my PSA tested twice a year and found it higher in the summer than the winter. I found if I stop riding 2 weeks before the test it returns to normal. My urologist is a cyclist and he explains that the higher PSA is due to inflammation from riding and not a indicator of cancer. This was confirmed by a test in February, one in March and one in April and it was normal, increased and returned to normal. Since I take a break before getting tested and it's been normal.
BTW, had a biopsy the first time to confirm i'm OK.
Saddle shape and saddle position all affect he amount of pressure you put on the prostate.
As to the "boyz", i'm hung like a gnat so they're not a problem.
Your typical "a$$ hatchet" but it is comfortable for me,