I ride a LWB recumbent so my hands don't carry any of my body weight. In fact, they just rest on the bars. However, I still get hand pain from road vibration transmitted though the relatively stiff front wheel and into the handle bars. All of these helped; folding bead front tire run at less that max pessure, padded gloves and two thicknesses of soft foam hand grips on each side.
I run the folding bead front tire at 65 psi while it has a max pressure of 100 psi. The lower pressure combined wi the flexible sidewalls really soak up most of the vibration. The others help too and it all adds up. Good luck. bk