Heldenberg already has knee pain, so I would advise not to make big changes in the wrong direction. So the first change should be rather small to limit the impact in case it is in the wrong direction. Often (at least in some books, like Zinn, Arnie Baker, and Priuitt) it is recommended to raise the saddle if the pain is in front or on the side, but I don't if that is a hard general rule. Caution in changing ride position was a key point made in "Road Racing, Techniques and Training" by Bernard Hinault and Claude Genzling. Claude migrated Bernhard to a different frame size, at the rate of about 1 mm per week. Of course then-Champion Hinault had legs worth a huge number of francs, but mine are quite valuable to me. It also tends to validate the idea that 1 mm changes are significant under some conditions.

But I'm not a doctor of any sort, just a cautious guy where it comes to my knees.