I'm not fanatical about it. With they way I rotate through them all they tend to get dusty and such. Normally as I take one out for the daily ride I'll give it a a quick swipe with a lysol wipe or too. If I notice any real grudge I'll wipe that down to. The a quick mist with Mothers detailing wax, wipe and done. Now a lot of the time here I deal with sections of wet road from the famers irrigating. That leaves a mess on the bike frame also. I try to remember to wipe that off before the bike goes back into the bike cave to await it's next turn.