I just had my annual physical and on reviewing the meds I take, my doctor expressed concern about taking oral NSAIDs on a regular basis to deal with my arthritis while riding (hands, neck, and shoulders). Apparently there is a risk of kidney damage, increasing with age (I'm 66). Instead, she suggested topical diclofenac for reduced systemic side effects. It helps, particularly with my hand discomfort, less so with the shoulders and neck. At this point, I can go for about 2-1/2 to 3 hours before the misery sets in. That has ruled out any century rides for me.

That said, I'm signed up for a 50 mile ride tomorrow (longest ride so far this year, although I did do 47 miles last week on my fixed gear), and the first group ride I've done in about a year and a half. 50 miles should be right on the threshold I've been able to tolerate this year. I may throw caution to the wind and take some naproxen before the ride, "just this once."