On my fx3 , I notice when I’m in the bigger ring (46/30), my drive train is not as smooth. I can hear more sound in the back derailer it’s not rubbing ,just more sound and my pedal strokes are not as smooth.
in the smaller one it rides way smoother,like butter, the shifting is about the same when moving up or down in the rear cogs.

is this true of all bikes and no matter what components you have ?

the fx3 has Acera, would it be same if I had deore, or Shimano 105 , tiagra...etc