Originally Posted by Kabuto

Of the options you've listed, the Domane and Roubaix have the highest stack, so that's something to consider if you'd prefer a more relaxed upright position. Not hugely so, but 10-20mm can/does make quite a difference. Unlike the other bikes, they also have "suspension": the Roubaix has the FutureShock and low mounted Pave seatpost designed to flex and the Domane has IsoSpeed front and rear). I have both bikes and their respective suspensions works well to dampen road buzz, but I much prefer the feel of the FutureShock 2.0 and Pave seatpost over the IsoSpeed. The Roubaix frame also feels way more responsive to me, and its a noticeably lighter bike. Both great bikes though.