Back in 2019 my wife and I did a supported trip on about 130 miles of the D&L trail from Glen Summit to Washington Crossing, and then back up the NJ side to Lumberton. I created a Cycleblaze journal with pictures you can see
here. We had a blast, even though we had a few deluge days.
The bridge in Jim Thorpe being finished eliminated one gap we had, the other big gap was around Allentown - not so bad.
The route we did was definitely doable self-supported, Pocono Biking and others offer shuttle service.
I would definitely put fenders on our bikes if we did the D&L again unless it was a guaranteed long dry stretch of weather!