Microspline is Shimano and XD/XDR are SRAM. No compatibility there. The new Shimano DA 12 is not Microspline. As I understand it, it accepts both the new Shimano 12 road cassettes and previous 11 speed cassettes. Microspline is required to use a 10T sprocket and shimano won't be making one for road.

XDR can be used with XD cassettes with a spacer or XDR cassettes.

When a 10T road cassette is used, it nearly always has a big ring of 50 or less. Sram makes pro level cranks with larger chain rings but that's usually to create specific ratios with the 11-12-13-14 and the 10 is almost never used.