Oh, especially on a long trip, it's also nice with more pannier room to not have to do a Tetris game every time you attempt to put everything away each morning.
Yes, we quickly get accustomed to where everything goes and how, but it is nice to have some leeway and to access stuff easier (main downside to pure bikepacking bags and much more limited volume).
This is especially true if you have to set up or break camp during inclement weather. I've taken to using a tarp over my tent when it looks like it might rain. With the tarp I can pack my panniers and fold up my tent whilst keeping everything and myself dry.
On a long trip comfort off the bike is very important as is the ability to have a good restful sleep.
Cheers