I find that my hands get sore if I find myself gripping the bars too hard. I try to continually remind myself not to grip the bars in a death grip all the time. During the summer I ride with some cheap-o fingerless gloves. They have minimal padding but generally do a good job of cushioning my hands while riding. I have a pair of merino wool gloves from Isadore for winter/cooler weather riding. They have no cushioning and if I am out for a 100k ride, my hands can start to get sore around the 60~70k mark.