There’s no law that states that you have to use ebike specific tires on an ebike.
If anything, it’s more the other way around.
With the support of the electric motor, there is less disadvantage to the rider from using a heavier tire with more rolling resistance. And, to cater to those using hub motors, some proper monsters of tires are born.
The ones I’ve encountered wouldn’t have looked out of place on a moped in structure and tread/wall thickness.

My ebike is a mid drive, and I’ve only been using regular bicycle tires with it.
Should I have a flat, it’s business as usual.
I have the winter wheels set up with ghetto tubeless though, Since a medical issue makes it near enough impossible for me to swap a tube under winter conditions.
Disc brakes IMO isn’t much of a deal.
Yes, you do need to remember not to pull the lever(on hydraulics) while the wheel is out.
And yes, you do need to spend a little effort getting the rotor to go in nicely between the pads. Not much to moan about.