I'm not sure what size tyre (width) you ride on but I've done 2,160km on Schwalbe Marathon Plus Reflex (one puncture) and 900km on Gatorskins (no punctures) - both in 25mm width as I can't go wider on the road bikes I currently use. I've not found any handling issues or lack of grip with either of them but the Gatorskins are lighter, much nicer to ride on and I'm confident that I'll be able to get them off and on during a roadside puncture - unlike the Schwalbe Marathon Plus Reflex which are an absolute pig.

I'm hoping to ride on wider tyres (at least 32mm) as soon as I finish building up a commuter bike with tidy clearances and will probably go with Gatorskins.

Postscript: Halfords in the UK have Schwalbe Marathon Plus in 35c at half price (£17 instead of £34) so I've grabbed a pair.