I've got many miles on a Giant Rapid 2 (2011) that I converted from a flat bar to drops. Today was my first ride on a Giant TCR 2 (2005). Only around 12 miles on the TCR but at least 2000 on the Rapid from weights of about 270 on down with no issues, if you don't count my body I've had good luck with the stock Giant S-R2 wheels and those from Alex XLC Pave on mostly 700x25 tires. No issues with them staying true, though I think one of the rears may be due later this year. Wheels that came with the TCR look a little spindly with lower spoke counts so saving those for when I'm closer to 200 pounds.

PS Loving the TCR!

Update: Recently popped a spoke on the Giant SR-2, after going about 1000+ miles. Dropping off a trail onto the road to avoid a crowd of walkers (didn't want to slow down). Later down the trail went to make a sharp turn and the rear did that familiar ping. Luckily I was able to ride at close to normal speed for several miles and get back home. Weight at ping was about 264 pounds. If you fear popping a spoke bring some black tape so you can tape the broken spoke to its buddy. That way you can limp home with less noise from the broken spoke hitting the frame or brakes every revolution. Time to get out for a ride because I know what I want for Christmas this year