I was on a fully loaded expedition style third world country tour. Trashed these tires in a month from sidewall damage on both. I was pissed because they cost over $70 per tire. This was back in 2010 so $70 back then was like $100 today. The front went first and I replaced it with a spare I was carrying, I think a Continental, maybe the Travel Contact model. I can't remember. Then the rear went and I replaced it with with an $8 Giant branded 29'er mountain bike tire I found in some bike shop in a village. Good times...
I actually have a Supreme on my bike right now. I think they are good tires for paved road riding. Next time I go on long tour I'll probably carry a Supreme as a spare.
Hmm Besides commuting, I've also used them for touring, loading over 30kg of bags, but I only use them tubeless, and only on tarmac or hard packed dirt. The sidewalls aren't the toughest on the Supremes, so bad roads with potholes etc will trash what is essentially a tarmac touring tire. When I need a tougher fast rolling tire, I switch to the Almotion Onestar TLE, which is a real tough touring tire, not like the Marathon + or + tour, but the only touring tire that allows tubeless in the Schwalbe range.