-s

With respect, it might.

While conventional tires can be pumped from zero with a typical hand or floor pump, that isn't the case with tubeless.

First of all, a flat tubeless tire sitting on the floor for a long time might lose sealant. The other issue can be inadequate air flow to re-seat the tire, and establish the seat so it'll hold air. Of course, these aren't insurmountable, but can be inconvenient. I assume the OP is thinking about that factor in asking his question.