I’ve got a 48/10-50 1x 12-speed setup on my road e-bike. My area is fairly flat, probably average 20-25 feet of ascent per mile. I occasionally ride with zero added power. It fine. Fine enough that I’ve been thinking of going to the same set up on my Roubaix. I’m not in the small ring terribly often except on a few punchy hills in the area. And with the 1x, I actually have a greater gearing range.