Yup. You'll see a lot of people talking about range but for flat road riding the jumps/gaps between gears is a bigger factor, and the range can be quite narrow.

It's worth comparing the exact gear ratios on different size cassettes to see where those jumps occur. All of SRAM's 12sp cassettes have single gear jumps on the small half. The 10-28 adds in that 16T cog, giving you 8 gears that are single tooth jumps.

If I had SRAM AXS, I'd have zero hesitation about running a 44T 1x setup with a 10-28 cassette for road riding. With my current setup (11sp with 44T front and 11-32 rear) I don't think I've ever used the 44x32 on the road.