I never put anything in my water bottles except water. I carry a food bottle with highly concentrated stuff, like 750 calories/bottle, a separate water bottle or hydration bladder, and a squeeze purse with Enduroyle caps. I separate out my food, water, and electrolytes because conditions change and one will need a different combination of those three depending on conditions. I might not use the Endurolytes at all or I might take 2/hour. Depends. I use the Endurolytes to create thirst if necessary. That's what they're for.