I have seen a road tire that has been used on a trainer later fall apart(almost) on the road. The tires in question were Michelin Pro4 service course, a pretty nice riding road tire. They had very little mileage before they went on the trainer. They were on my girlfriend's bike. She would come and ride with me about 50% of the time that I did almost always quitting about 2/3 of the way through my workout. They probably only had 10-15 hours on the trainer. Once we actually started riding outdoors I was riding 3 times as much as she was, but less than halfway through the summer her rear tire started splitting in the middle of the tread. My take is don't ever use really good tires on a trainer