That is a lot to disregard. The plus weighs something like twice as much and has very stiff sidewalls so if you value a lively ride feel forget that. That said yes it is very puncture resistant. Goathead thorns and tire wires may eventually get through, but it will happen way less often.

FWIW, I tried going that exact route going from gatorskins to marathon pluses at some point in the past. I hated the ride so much I pulled them off and sold them. I put some new gatorskins on again.

I have had such good luck with tubeless on my mountain bike I may consider going tubeless on my next touring setup.. I went from weekly thorn flats to pretty much never flatting with tubeless on my MTB.