No pain while riding. My calves fatigue on extended rides or climbs (70 miles, or 4500 ft climbing or various, more difficult gravel routes). I guess fatigue can be considered painful but it is most often that evening/night after or next day.
To me, the symptom getting my attention is that it is always my calves and only my calves. I can do a century ride and no other muscle is bothered by it.