I'm wondering how your saddle setback was determined. KOP is often recommended, but I've always used a further back position, since I do a lot of climbing. Your do look to be pedaling too much toes down, which might mean you're saddle is too high. I've got well developed calf muscles too, but never have calf soreness. I've been surprised have some of today's best pro GC riders don't have big calves.
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