I bolted mine to a 2x8. Notice that I've got a qr mount next to a thru-axle mount, so I can take a newer bike or an older one.

Couple tips:
1) It's easiest to maneuver the bike in and out of the vehicle if you stick the rear wheel in first...Then you can fiddle with the front dropout more easily from the hatchback area.
2) This will work better or worse depending on your bike's size and the model year of your CR-V. I ride 58 frames, so a bit longer wheelbase than some. It's a tight fit in our 2011 CR-V, since that has rear seats that fold up against the front seats, thus reducing the length of the cargo space. In that car, I have to wedge the bike in sideways, which restricts room for other cargo. On our 2022 CR-V, the rear seats fold down, and so there's more room for a bike to be parked lengthways. (I don't know when the design changed.)