My weight has fluctuated between 240 and 270 for far longer than I'd like.
As others have pointed out, wheels will most likely fail before a decent frame. Eight years ago I built up my current road ride. I went with a set of wheels built with Mavic Open Pro 32 spoke 700C rims, DT Swiss spokes and Shimano 105 (5800) hubs - from Velomine. They've held up to everything I've put them through.