I have Hunt 50s with tubeless Conti 5000s on one aero bike and Mavic Ksyrium Elites with tubed Conti 5000s with Michelin light weight tubes in the other aero bike. Switching to the Hunts with tubeless made a huge difference from the carbon 30s it came with. Switching the tires and tubes on the other made a remarkable change over the heavier tubes and stock tires on the Mavics. Each change was substantial but can’t say one was far greater than the other. However switching out the Mavics to carbon Aeros (probably 45s would be a compromise of weight and aero) would probably yield another jump.
So a cost effective gain would be to upgrade tires and tubes. A more expensive but better upgrade would of course be carbons with tubeless. It just depends on your finances.
__________________
“A watt saved is a watt earned” 🚴🏻♂️
Not a CAT