It depends on your metabolic state at the time. After a few hours of moderate to hard going, available glycogen (stored carbohydrate) is depleted and the answer is an emphatic yes. After 30 min of tootling along at a conversational pace, no.
Incidentally, in the glycogen depleted state, most ingested sugar will be used for immediate energy needs and only about a maximum of a third (IIRC), if any, will be stored as glycogen. Moreover, in that state, glucose uptake into muscle is insulin-independent and immediate, hence it has very different health implications from sitting on the couch and eating Cap'n Crunch, i.e., very unlikely to have detrimental effects.